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Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models

Many research have proven each the CD28-D80/86 costimulatory pathway and the PD-1-PD-L1/L2 coinhibitory pathway to be necessary indicators in modulating or reducing the inflammatory profile in ischemia-reperfusion damage (IRI) or in a stable organ transplant setting. The significance of those two opposing pathways and their potential synergistic impact led our group to design a human […]

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Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity.

Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity.

Congenital human cytomegalovirus (HCMV) an infection and HCMV an infection of immunosuppressed sufferers trigger important morbidity and mortality, and vaccine improvement towards HCMV is a serious public well being precedence. HCMV envelope glycoproteins gB, gH, and gL, which represent the core fusion equipment, play essential roles in HCMV fusion and entry into host cells. HCMV […]

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Development of a Multi-Epitope Recombinant Protein for the Diagnosis of Human Visceral Leishmaniasis

Development of a Multi-Epitope Recombinant Protein for the Diagnosis of Human Visceral Leishmaniasis

Iran is without doubt one of the endemic areas of Mediterranean Visceral Leishmaniasis, a illness attributable to Leishmania infantum. On this work, we examined whether or not Proteína quimérica 10 (PQ10) recombinant protein is appropriate for immunological prognosis of human visceral leishmaniasis. We now have used a recombinant artificial protein to enhance serodiagnosis of human visceral […]

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