| Description: |
VEGFR-1 belongs to a family of five receptor tyrosine
kinase receptors that are specific to a number of
angiogenic factors including VEGF and PDGF, and are
therefore thought to play a role in the angiogenic process.
VEGFR-1 is expressed in two forms, predominantly on
endothelial cells, giving rise to a full-length membrane
bound receptor and a truncated soluble receptor.
Elevated levels of the soluble form of this VEGF receptor
may be used in the diagnosis of pathological conditions.
RANDOX recombinant VEGFR-1 comprises a 298
amino acid fragment (31-328) corresponding to the IgGlike
domains 1-3 from the mature soluble VEGFR protein.
VEGFR-1 is expressed in E. coli with an amino-terminal
hexahistidine tag. This product is for research use only
and is not intended for diagnostic or therapeutic use.
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| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM
DTT,
1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).
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| Purity:
|
Single band on Western blot.
|
| References:
|
Starovasnik, M. A et al. (1999) J. Mol. Biol. 296 (3) : 531-
544.
Kanno, S. et al. (2000) Oncogene 19 (17) : 2138-2146.
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| Datasheet: |
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