| Description: |
The term ‘PDGF’ refers to a family of disulphide bondlinked
dimeric isoforms that act as autocrine and
paracrine growth factors and are produced by a variety of
cell types other than platelets. They act as potent
mitogens for almost all mesenchymally-derived cells.
Aberrant expression is involved in certain cancers,
fibroproliferative disorders and atherosclerosis. The
protein also contributes to wound healing and neural
regeneration. There are four members of the PDGF
family – PDGF A, PDGF B, PDGF C and PDGF D.
.
RANDOX recombinant PDGF-B comprises a 109 amino
acid fragment (82-190) corresponding to the mature
PDGF-B chain protein and is expressed in E. coli with an
amino-terminal hexahistidine tag. This product is for
research use only and is not intended for diagnostic or
therapeutic use
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| Form:
|
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM
DTT,
1%(w/v) SDS, 0.1%(w/v) Bromophenol Blue, 2.5% Glycerol).
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| Purity:
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Single band on Western blot.
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| References:
|
Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) :
5154-5160.
Heldin, C.H. (1992) EMBO J. 11(12) : 4251-4259.
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| Datasheet: |
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