| Description: |
The term ‘PDGF’ refers to a family of disulphide bondlinked
dimeric isoforms that act as autocrine and
paracrine growth factors and are produced by a variety of
cell types other than platelets. They act as potent
mitogens for almost all mesenchymally-derived cells.
Aberrant expression is involved in certain cancers,
fibroproliferative disorders and atherosclerosis. The
protein also contributes to wound healing and neural
regeneration. There are four members of the PDGF
family – PDGF A, PDGF B, PDGF C and PDGF D. Two
distinct types of PDGF-A exist – a short form that is
soluble and a long form that is retained by the
extracellular matrix.
RANDOX recombinant PDGF-A comprises a 110 amino
acid fragment (87-196) corresponding to the mature
PDGF-A short chain protein and is expressed in E. coli
with an amino-terminal hexahistidine tag. This product is
for research use only and is not intended for diagnostic or
therapeutic use
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| Synonyms:
|
Glioma-derived growth factor, GDGF, Osteosarcoma-derived Growth Factor, ODGF, PDGF-A, PDGF-1.
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| Form:
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Liquid
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| Purity:
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>95% by SDS-PAGE
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| References:
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Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) : 5154-5160.
Bonthron, D.T. et al. (1988). Proc. Natl. Acad. Sci USA 85(5):
1492-1496.
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| Datasheet: |
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