| Description: |
PAI-1 is a serine protease inhibitor, which can exist either in an
active inhibitory conformation or in an inactive or latent
conformation. PAI-1 is produced mainly by the endothelium but is
also secreted by other tissue types including adipose tissue. PAI-1
is the principal inhibitor of tissue plasminogen activator and
urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1
have been linked with various conditions including cardiovascular
disease, thrombosis, insulin resistance and obesity.
RANDOX recombinant PAI-1 comprises a 379 amino acid
fragment (24-402) corresponding to the mature PAI-1 protein and is
expressed in E. coli with an amino-terminal hexahistidine tag. This
product is for research use only and is not intended for diagnostic
or therapeutic use.
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