| Description: |
PAI-1 is a serine protease inhibitor, which can exist,
either in an active inhibitory conformation or in an inactive
or latent conformation. PAI-1 is produced mainly by the
endothelium but is also secreted by other tissue types
including adipose tissue. PAI-1 is the principal inhibitor of
tissue plasminogen activator and urokinase, therefore
inhibiting fibrinolysis. Increased levels of PAI-1 have been
linked with various conditions including cardiovascular
disease, thrombosis, insulin resistance and obesity.
RANDOX recombinant PAI-1 comprises a 379 amino
acid fragment (24-402) corresponding to the mature PAI-
1 protein and is expressed in E. coli with an aminoterminal
hexahistidine tag. This product is for research
use only and is not intended for diagnostic or therapeutic
use.
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| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8,
50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol
Blue, 2.5% Glycerol).
|
| Purity:
|
Single band on Western blot
|
| References:
|
Gils, A & Declerck, P.J. 2004 Curr. Med. Chem. 11 (17) :
2323- 2334.
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| Datasheet: |
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