| Description: |
NSE is the γγ isoform of the glycolytic enzyme enolase
and is expressed primarily in neurons, in normal and
neoplastic neuroendocrine cells . NSE is a highly soluble
cytoplasmic protein that is readily secreted into the CSF
and serum following tissue damage. NSE shows
neurotrophic and neuroprotective properties on a broad
spectrum of central nervous system (CNS) neurons and
binds in a calcium-dependent manner to cultured
neocortical neurons promoting cell survival.
RANDOX recombinant NSE comprises a 433 amino
acid fragment (2-434) corresponding to processed mature
NSE protein and is expressed in E. coli with an aminoterminal
hexahistidine tag. This product is for research
use only and is not intended for diagnostic or therapeutic
use.
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| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8,
50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol
Blue, 2.5% Glycerol).
|
| Purity:
|
Single band on Western blot
|
| References:
|
Kaiser, E. et al.,(1989) Clin. Chim. Acta. 183 (1) :13-31.
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| Datasheet: |
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