| Description: |
MCP-1 is a member of the CC subgroup of the
chemokine superfamily. It is produced by a variety of cell
types including monocytes, lymphocytes, endothelial cells
and fibroblasts after stimulation by any inflammatory
mediator. MCP-1 acts as a potent chemoattractant and is
thought to play an important role in the inflammatory
response of blood monocytes, tissue macrophages and
natural killer cells. Its expression has been documented in
disorders characterized by mononuclear cell infiltrates,
suggesting that it may contribute to the inflammatory
component of diseases such as atherosclerosis, multiple
sclerosis, or rheumatoid arthritis.
.
RANDOX recombinant MCP-1 comprises a 76 amino
acid fragment (24-99) corresponding to the mature MCP-
1 protein and is expressed in E. coli with an aminoterminal
hexahistidine tag. This product is for research
use only and is not intended for diagnostic or therapeutic
use.
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| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8,
50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol
Blue, 2.5% Glycerol).
|
| Purity:
|
Single band on Western blot.
|
| References:
|
Gu, L. et al., 1997 J Leukoc. Biol. 62 (5) : 557-580.
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| Datasheet: |
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