| Description: |
Integrin-linked kinase (ILK1) is a serine/threonine protein kinase, containing 4 ankyrin-like repeats. ILK1 interacts with the cytoplasmic domains of integrin β1 and β3 subunits as well as several adaptors and signalling proteins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. ILK1 has been reported to regulate a number of biological properties including anchorage-independent cell cycle progression, tumour cell invasion and apoptosis. Over-expression of ILK1 has been documented in a wide variety of human malignancies. RANDOX recombinant ILK1 comprises a 452 amino acid fragment (1-452) corresponding to the mature ILK1 full-length protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
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| Form:
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Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).
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| Purity:
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Single band on Western blot.
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| References:
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Hannigan G.E. et al Nature. 1996. 379 (6560) : 91-6. Marotta A. et al, BJC 2003 88 :1755-1762
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| Datasheet: |
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