Hepatocyte Growth Factor B Protein
Human Recombinant Protein Specification
Hepatocyte growth factor regulates cell growth, cell motility, and
morphogenesis by activating a tyrosine kinase-signalling cascade.
Hepatocyte growth factor is secreted by mesenchymal cells and
acts as a multi-functional cytokine on cells of mainly epithelial
origin. Its ability to stimulate mitogenesis, cell motility, and matrix
invasion gives it a central role in angiogenesis, tumorogenesis, and
tissue regeneration. It is secreted as a single inactive polypeptide
and is cleaved by serine proteases into a 69-kDa alpha-chain and
34-kDa beta-chain. A disulfide bond between the alpha and beta
chains produces the active, heterodimeric molecule.
RANDOX recombinant HGF-B comprises a 234 amino acid
fragment (495-728) corresponding to the mature HGF-B protein
and is expressed in E. coli with an amino-terminal hexahistidine
tag. This product is for research use only and is not intended for
diagnostic or therapeutic use.
>95% by SDS-PAGE
Miyazawa, K. et al (1993) Journal of Biological Chemistry 268 :
Shimomura T. et al (1992) Cytotechnology 8 : 219-229.