| Description: |
Tissue polypeptide specific antigen was first identified as
a tumour marker in the late 1950’s, but has recently been
shown to be closely related to human cytokeratin 18.
Cytokeratins are a group of about 20 cytoskeletal
proteins, whose degradation gives rise to soluble
fragments, measurable in the blood of patients. Serum
levels are high in breast cancer patients and also some
other malignancies, probably due to high cell turnover in
tumours.
RANDOX recombinant human CK-18 is expressed in E.
coli with an amino-terminal hexahistidine tag. This
product is for research use only and is not intended for
diagnostic or therapeutic use.
|
| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM
DTT,
1%(w/v) SDS, 0.1%(w/v) Bromophenol Blue, 2.5% Glycerol).
|
| Molecular Weight:
|
51.6 kDa
|
| Purity:
|
Single band on Western blot.
|
| References:
|
D'Alessandro, R. et al. (2001) Breast Cancer Res. Treat.
68(1): 9-19.
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| Datasheet: |
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