Phencyclidine, 1-phenylcyclohexylpiperidine, is also known as PCP and ‘angel dust’ (1, 2). It is a synthetic drug developed in the 1950s as an anaesthetic and analgesic but was removed from the market due to its hallucinogenic properties and the unpredictable behavioural reactions, which occurred following anaesthesia (3, 5). PCP is used by smoking with tobacco or marijuana, nasal insufflation (snorting), intravenous injection and oral ingestion (3, 5). It is a drug of abuse due to its euphoric and hallucinogenic effects. However, these effects can get quite erratic, with violent or bizarre behaviour often occurring (4).
1. Gupta RC., Lu I., Oei G. and Lundberg GD. Determination of phencyclidine (PCP) in urine and illicit street drug samples, Clin. Toxicol. 1995, 8(6): 611-621. 2. Beselt RC, Urine Drug Screening by Immunoassay: Interpretation of Results. In: Beselt RC, Advances in Analytical toxicology, Biomedical Publications, California, 1984, vol 1, 81-123 . 3. Schneiders S., Kuffer P. and Wennig R, Determination of lysergide (LSD) and phencyclidine in biosamples, Journal of Chromatography B, 1998, 713: 189-200. 4. Eskridge KD. and Guthrie SK. Clinical issues associated with urine, Pharmacotherapy, 1997, 17(3): 506-507. 5. Wild D. (ed), The Immunoassay Handbook, second edition, Nature Publishing Group, London, Basingstoke, New York, 2001, 808-810.