| Description: |
The term ‘PDGF’ refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family – PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist – a short form that is soluble and a long form that is retained by the extracellular matrix. RANDOX recombinant PDGF-A comprises a 110 amino acid fragment (87-196) corresponding to the mature PDGF-A short chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
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| PH:
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7.2
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| Application:
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ELISA, Western Blot, Dot Blot, Immunohistology chemistry, Immunoassays, Development of Rapid tests and other immunoassay,antibody recognition assays
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| Buffer:
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20mM Phosphate, 150mM Sodium Chloride, pH 7.2
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| Format:
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Affinity purified Ig
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| Host:
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Sheep
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| Immunogen:
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Recombinant Human PDGFA
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| Lot:
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RS750-06
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| Preservative:
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0.09% Sodium Azide
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| Storage:
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≤ -20C, avoid repeated freeze/thaw cycles
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| References:
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Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) : 5154-5160. Bonthron, D.T. et al. (1988). Proc. Natl. Acad. Sci USA 85(5): 1492-1496.
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| Datasheet: |
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