| Description: |
PAI-1 is a serine protease inhibitor, which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. RANDOX recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
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| PH:
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7.2
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| Application:
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ELISA, Western Blot, Dot Blot, Immunohistology chemistry, Immunoassays, Development of Rapid tests and other immunoassay,antibody recognition assays
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| Buffer:
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20mM Phosphate, 150mM Sodium Chloride, pH 7.2
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| Format:
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Affinity purified Ig
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| Host:
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Sheep
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| Immunogen:
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Recombinant Human PAI-1
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| Lot:
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RS1043-03
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| Preservative:
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0.09% Sodium Azide
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| Storage:
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≤ -20C, avoid repeated freeze/thaw cycles
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| References:
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Gils, A & Declerck, P.J. 2004 Curr. Med. Chem. 11 (17) : 2323- 2334
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| Datasheet: |
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