| Description: |
This nuclear receptor functions as a transcription factor
and plays an important role in controlling differentiation
and fatty acid metabolism. Activation of this receptor
appears to be vital in modulating the expression of
metabolic control proteins and consequently controlling
fatty acid metabolism in cardiac muscle. This marker
may be a useful drug target for therapeutic intervention in
cardiac disease. PPARγ is also involved in the
pathogenesis of important metabolic disorders such as
obesity and non-insulin-dependent diabetes (NIDDM).
RANDOX recombinant human PPARγ is expressed in
E. coli with an amino-terminal hexahistidine tag. This
product is for research use only and is not intended for
diagnostic or therapeutic use.
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| Form:
|
Liquid.
Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM
DTT,
1%(w/v) SDS, 0.1%(w/v) Bromophenol Blue, 2.5% Glycerol).
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| Molecular:
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59.2kDa
|
| Purity:
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Single band on Western blot.
|
| References:
|
Schiffrin, E.L. et al. (2003) Hypertension. 42(4): 664-8
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| Datasheet: |
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