Oxycodone(6)

catalogue:	size:	price:	qty:
PAS9712	100µl	£308.23

Description:

Oxycodone is a semi-synthetic opioid structurally related to other members of the opioid class(17) and derived from the opium alkaloid thebaine(18). It has both analgesic and anti-tussive properties(19) and has been used for the treatment of moderate to severe postoperative or cancer related pain(20). In analgesic potency it is comparable to morphine with its most dangerous potential side-effect being respiratory depression(18). Fatalities due to oxycodone overdose are usually due to respiratory depression to the level of respiratory arrest(21).

Buffer:

20mM Phosphate, 150mM Sodium Chloride, pH 7.2

Format:

Ig fraction

Host:

Sheep

Ig Con:

8.33mg/ml (U.V. abs @ 280nm)

Immunogen:

Oxycodone(6)-BSA

Lot:

RS253-19

Preservative:

0.09% Sodium Azide

Storage:

≤ -20C, avoid repeated freeze/thaw cycles

Work Con:

2μg/ml (EIA)

References:

17. Baldacci A., Caslavska J., Wey AB and Thormann W. Identification of new oxycodone metabolites in human urine by capillary electrophoresis-multiple-stage ion-trap mass spectrometry. J Chromatogr A. 2004, 1051(1-2): 273-282. 18. Le N.L., Reiter A., Tomlinson K., Jones J. and Moore C. The detection of oxycodone in meconium specimens. J Anal Toxicol. 2005. 29(1): 54-57. 19. Moore KA., Ramcharitar V., Levine B. and Fowler D. Tentative identification of novel oxycodone metabolites in human urine. J Anal Toxicol. 2003, 27(6): 346-352. 20. Poyhia R., Seppala T., Olkkola KT. and Kalso E. The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects. Br J. Clin Pharmacol. 1992, 33 (6): 617- 621. 21. Abadie JM., Allison KH., Black DA., Garbin J., Saxon AJ., and Bankson DP. Can an immunoassay become a standard technique in detecting oxycodone and its metabolites? J. Anal. Toxicol. 2005, 29 (8): 825-829.

Datasheet:

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Polyclonal Antibody Specification

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