| Description: |
Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children and as an adjunct to analgesics for certain chronic and neuropathic pain syndromes. Whilst therapeutic drug monitoring (TDM) of TCA’s is well established in the treatment of depression, TCA overdose remains the most common cause of death from prescription drugs(1, 2).
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| Application:
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The antibody is suitable for the development of immunoassays or immunoaffinity purification
columns.
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| Buffer:
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20mM Phosphate, 150mM Sodium Chloride, pH 7.2
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| Footer:
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For in vitro use only, research applications not intended for diagnostic or therapeutic purposes
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| Format:
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Ig fraction, liquid
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| Host:
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Sheep
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| Ig Con:
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6.38 mg/ml (U.V. abs at 280nm)
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| Immunogen:
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Desipramine-BTG
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| Lot:
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RS1029-12
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| Preservative:
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0.09% Sodium Azide
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| Related:
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Desipramine-HRP Cat. No. HRP9422, size 0.5 ml
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| Sensitivity:
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10 ng/ml desipramine produces 20% inhibition
in a competitive ELISA, employing desipramine
polyclonal antibody.
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| Specificity:
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Data not yet available.
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| Storage:
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≤ -20C, avoid repeated freeze/thaw cycles
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| Work Con:
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2.5 μg/ml (ELISA microtitre plate based)
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| References:
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1. Haddad L.M. Managing tricyclic antidepressant overdose. Am. Farm. Physician. 1992, 46 (1): 153-159. 2. Pimentel L. and Trommer L-Cyclic antidepressant overdoses. A review. Emerg. Med. Clin. North. Am. 1994, 12 (2): 533-547.
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| Datasheet: |
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